Cheaper, safer: Addition reactions of sulfonylimidates to imines are catalyzed by alkaline-earth-metal alkoxide salts, which are abundant, inexpensive, and nontoxic. Diastereoselectivity is highly dependent on solvent and catalyst, and both syn and anti adducts are obtained in high yields and with high diastereoselectivity (see scheme). The first catalytic asymmetric Mannich-type reaction of a sulfonylimidate is also presented.
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Nguyen et al. (2009) studied this question.
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