The reactions of 2,3‐dimethyl‐ (4), 2,3‐diphenyl‐ (6), and 2‐methyl‐3‐phenyl‐pyrazine monoxides (8 and 9) with phosphoryl chloride and acetic anhydride resulted in giving monochloro‐ and monacetoxy‐pyrazines in almost all cases. However, the reaction of 6 with acetic anhydride afforded exceptionally a diacetoxydihydro‐pyrazine. These products were converted further to hydroxy or dichloro derivatives.
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Ohta et al. (1982) studied this question.
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