Key result
Among 715 children hospitalized with severe acute respiratory illness in Panama and El Salvador, 17 (2.4%) were positive for EV-D68, which was significantly associated with a history of asthma.
Observational (n=715)
Yes
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EV-D68 strains circulating in Central America during 2012-2013 were phylogenetically related to contemporaneous strains from the Americas and commonly associated with asthma or wheezing in hospitalized children.
We assessed EV-D68 epidemiology and phylogenetics among children aged ≤9 years hospitalized with severe acute respiratory illnesses at five sites in Panama and El Salvador during 2012-2013. Respiratory specimens positive for enterovirus or rhinovirus were tested by real-time RT-PCR for EV-D68, and partial VP1 gene sequences were determined. Of 715 enrolled children, 17 from sites in both countries were EV-D68-positive and commonly had a history of asthma or wheezing. Phylogenetically, 15 of 16 sequences fell into Clade B1, and one into Clade A2. The Central American EV-D68s were closely related genetically to contemporaneous strains from North America, South America, and the Caribbean.
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Biggs et al. (2020) conducted an observational in Severe acute respiratory illness (n=715). Enterovirus D68 infection vs. No EV-D68 infection was evaluated on Prevalence of EV-D68 infection. Among 715 children hospitalized with severe acute respiratory illness in Panama and El Salvador, 17 (2.4%) were positive for EV-D68, which was significantly associated with a history of asthma.
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