An efficient strategy has been established for the enantiodivergent synthesis of natural product inspired compounds embodying both tropane and pyrrolidine natural product fragments. This strategy includes the enantioselective kinetic resolution of racemic tropanes by means of a copper(I)‐catalyzed [3+2] cycloaddition and allows the preparation of two enantiopure products in a one‐pot reaction in high yield and with high diastereo‐ and enantioselectivity by using one chiral catalyst.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: