Key result
Perfusion with propranolol at 50.0 microgram/ml abolished the inverse relationship between inferior cardiac nerve activity and carotid sinus pressure, while 5.0 microgram/ml produced no change.
Why the study?
Does propranolol perfusion alter the relationship between inferior cardiac nerve activity and carotid sinus pressure in cats?
Does propranolol perfusion alter the relationship between inferior cardiac nerve activity and carotid sinus pressure in cats?
High concentrations of propranolol abolish the inverse relationship between inferior cardiac nerve activity and carotid sinus pressure in cats, suggesting it does not enhance this neurophysiological component of the reflex depressor response.
Answers are grounded in this paper and cite their sources.
High-dose propranolol disrupts this baroreflex component in cats; leaves open any role in human sympathetic regulation.
1 Inferior cardiac nerve activity in 9 cats was in inverse relationship to the pressure maintained in the systemically isolated and perfused carotid sinus. 2 Perfusion with propranolol produced no change in this relationship at a concentration of 5.0 microgram/ml, but abolished it at 50.0 microgram/ml. 3 The results suggest that concentrations of propranolol which have been reported to enhance the sensitivity of the carotid sinus to pressure do not enhance one neurophysiological component of the reflex depressor response.
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McCleary et al. (1980) studied this question. Propranolol was evaluated on Inferior cardiac nerve activity in relation to carotid sinus pressure. Perfusion with propranolol at 50.0 microgram/ml abolished the inverse relationship between inferior cardiac nerve activity and carotid sinus pressure, while 5.0 microgram/ml produced no change.
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