Bilirubin added to the ambient fluid in concentrations above 20 to 25 mg % depresses the respiration of chopped rat brain by approximately 25%. This inhibition can be counteracted by oxidation of the bilirubin and by the action of methylene blue on the bilirubin. Cytochrome C also reverses the inhibition. The mechanisms of these reversals appear to be different.
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Randy Day (1954) studied this question.
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