Benign Recurrent Intrahepatic Cholestasis

INTRAHEPATIC cholestasis as a manifestation of liver disease is not an unusual finding. Such obstruction to bile flow may occur quite frequently in acute and chronic hepatitis and primary biliary cirrhosis and occasionally follows the use of therapeutic agents such as chlorpromazine.1 It may also occur in alcoholic patients having a fatty liver,2 as well as in erythroblastosis fetalis,3 intrahepatic biliary atresia4 and the so-called idiopathic jaundice of pregnancy.5 However, in all these conditions, except for the idiopathic jaundice of pregnancy, it is most unusual to have repeated or recurrent episodes of cholestasis, without the presence of some extrahepatic obstruction. . . .