Key result
Patients with acute cerebrovascular disease maintained mean blood pressure and exhibited decreases in common carotid blood flow during head-up tilt that were similar in magnitude to healthy elderly controls.
Why the study?
Does head-up tilt alter carotid blood flow and cardiovascular responses differently in patients with acute cerebrovascular disease compared to healthy controls?
Cross-Sectional (n=52)
No
Does head-up tilt alter carotid blood flow and cardiovascular responses differently in patients with acute cerebrovascular disease compared to healthy controls?
Patients with acute cerebrovascular disease and supratentorial lesions maintain normal cardiovascular and carotid blood flow responses during upright posture, suggesting early mobilization is physiologically safe.
May support early mobilization safety in acute cerebrovascular disease; leaves open need for prospective trials on clinical outcomes.
The purpose of this study was to define common carotid blood flow (CBF), cardiovascular and endocrine responses during head-up tilt (HUT) in patients with acute cerebrovascular diseases (CVD). In 31 male patients with acute CVD (damage of the supratentorial area) and 21 age-matched control male subjects, we measured CBF, mean blood pressure (MBP), heart rate, stroke volume and cardiac output responses before (baseline), during and after HUT. We also measured plasma levels of antidiuretic hormone, adrenaline, noradrenaline, aldosterone and plasma renin activity. After obtaining baseline measurements during 3-minutes horizontal position, HUT was performed for 5 minutes, followed by continuation of recording for 3 more minutes in the horizontal position. During HUT, CBF decreased significantly and equally in both groups. MBP did not change during HUT in both groups. The endocrine responses were also not different between the two groups. The results suggest that damage to the supratentorial area in patients with acute CVD do not alter the CBF, cardiovascular and endocrine responses. In other words, HUT does not predispose patients with acute CVD to serious falls in MBP and CBF at upright posture.
No takes yet. Share an insight, caveat, or question.
Miyake et al. (2014) conducted a cross-sectional in Acute cerebrovascular disease (CVD) (n=52). Acute cerebrovascular disease (supratentorial lesion) vs. Healthy age-matched controls was evaluated on Changes in mean blood pressure (MBP) and common carotid blood flow (CBF) during head-up tilt. Patients with acute cerebrovascular disease maintained mean blood pressure and exhibited decreases in common carotid blood flow during head-up tilt that were similar in magnitude to healthy elderly controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: