Key result
Imatinib temporarily ameliorated severe pulmonary hypertension caused by pulmonary tumor thrombotic microangiopathy, allowing the patient to be weaned from percutaneous cardiopulmonary support.
Why the study?
Does imatinib improve pulmonary hypertension and circulatory failure in a patient with pulmonary tumor thrombotic microangiopathy?
Case Report (n=1)
No
Does imatinib improve pulmonary hypertension and circulatory failure in a patient with pulmonary tumor thrombotic microangiopathy?
Imatinib may temporarily ameliorate severe pulmonary hypertension and circulatory failure caused by pulmonary tumor thrombotic microangiopathy, allowing for weaning from mechanical support.
Hypothesis-generating for imatinib in PTTM-associated PH; prospective validation required before clinical adoption.
Pulmonary tumor thrombotic microangiopathy is a lethal, yet difficult to diagnose, complication of gastrointestinal carcinoma. Even if properly diagnosed, there is no treatment, especially after a circulatory collapse. We herein report a case of pulmonary tumor thrombotic microangiopathy with circulatory failure due to pulmonary hypertension. The patient was temporarily successfully treated with imatinib, an inhibitor of the platelet-derived growth factor receptor. Pulmonary hypertension was dramatically ameliorated and the patient was able to be weaned from percutaneous cardiopulmonary support within 20 days of treatment. Imatinib may be effective for ameliorating pulmonary hypertension that is caused by pulmonary tumor thrombotic microangiopathy.
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Ogawa et al. (2013) conducted a case report in Pulmonary tumor thrombotic microangiopathy with circulatory failure (n=1). Imatinib was evaluated on Clinical improvement (weaning from percutaneous cardiopulmonary support and amelioration of pulmonary hypertension). Imatinib temporarily ameliorated severe pulmonary hypertension caused by pulmonary tumor thrombotic microangiopathy, allowing the patient to be weaned from percutaneous cardiopulmonary support.
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