Molecular analysis reveals extensive 3'-terminal sequence homology across cherry leaf roll nepovirus RNAs and isolates, suggesting an essential non-coding role in viral replication.
A series of cDNA clones has been made from the birch isolate of cherry leaf roll nepovirus. Restriction enzyme analysis and sequencing showed that at the 3' end, RNA-1 and RNA-2 are identical for 1.5 kb. Also a 0.7 kb 3' end homology exists between the birch and rhubarb isolate. These sequences do not seem to code for any proteins; however, the sequence conservation points to a role in virus replication.
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Scott et al. (1992) studied this question.
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