Jaydess® levonorgestrel intrauterine system

Intrauterine contraception is available as either copper-containing intrauterine devices (Cu-IUDs) or a levonorgestrel intrauterine system (LNG-IUS).1 Until recently the Mirena® LNG-IUS (Bayer plc) which contains 52 mg levonorgestrel has been the only licensed LNG-IUS available in the UK. Jaydess® (Bayer plc) is a LNG-IUS that was launched in the UK market in April 2014. It has been designed with smaller dimensions than Mirena. As a result the LNG content and release rate are lower (Tables 1 and 2). It is known as Skyla® in the USA, where it has been licensed since 2013.6 Jaydess will not replace Mirena but is instead intended to afford women greater contraceptive choice. The differences and similarities between Jaydess and Mirena are summarised in Box 1.7 View this table: Table 1 Product differentiation between Jaydess® and Mirena® View this table: Table 2 Levonorgestrel release rates and serum levels* associated with the Jaydess® and Mirena® intrauterine systems Box 1 ### Key differences and similarities between Jaydess® and Mirena® (adapted from Ref. 7 with permission) Key differences from the Mirena LNG-IUS