Carbometalation: Cobalt salts catalyze benzylzincation of alkynes to afford benzylated multisubstituted alkenes with high regio- and stereoselectivity. The scope of the reaction is wide enough to apply unfunctionalized alkynes as well as arylacetylenes. The reaction offers a new route to the regio- and stereoselective synthesis of an estrogen receptor antagonist (see scheme).
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Murakami et al. (2010) studied this question.
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