An efficient and practical chemo‐enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6‐tetramethylpiperidine 1‐oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio‐oxidation of a series of primary, secondary and cyclic amines has been achieved. magnified image
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Galletti et al. (2015) studied this question.
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