Key result
FLOT-1 expression was positive in 54% of serous ovarian carcinomas and was significantly associated with the grade of tumor differentiation (p=0.000).
Why the study?
The pathogenesis of ovarian cancer remains poorly understood, and the role of FLOT-1 in ovarian serous carcinogenesis is not clear.
Observational (n=72)
p-value: p=0.000
FLOT-1 expression was associated with tumor grade; hypothesis-generating for prognostic utility in serous ovarian carcinoma.
Background: Ovarian cancer is one of the most common cancers among females worldwide. Its pathogenesis is not well understood till now. FLOT-1 is expressed in a wide range of normal and neoplastic tissues and has emerged as an important regulator cellular adhesion, proliferation, and metastasis. Its role in ovarian serous carcinogenesis is not clear and needs further studies. Methods:The present study comprised 72 cases of serous ovarian tumors including; 50 (69.44%) cases of serous ovarian carcinoma, 12 (16.67%) cases of borderline serous ovarian tumors and 10 (13.89%) cases of serous ovarian cyst-adenoma. Immunohistochemistry for FLOT-1 antibody was performed using the avidin biotin-peroxidase complex method. Results: FLOT-1 was positive in 54% of serous ovarian carcinoma cases, 50% of borderline cases were positive and all serous cystadenoma cases were negative. Statistically significant association was detected between FLOT-1 expression and grade of differentiation of serous ovarian carcinoma cases (p=0.000). Meanwhile, no statistically significant association was found between FLOT-1 expression and age, tumor size, tumor bi-laterality and tumor stage (p=0.179, 0.643, 0.093, 0.187 respectively). In serous borderline cases, there were no statistically significant association between FLOT-1 expression and age, tumor size and tumor bi-laterality (p=0.558, 0.558, 0.121 respectively). Conclusions: FLOT-1 expression is significantly associated with poor prognostic factors and thus can be used as a prognostic indicator for serous ovarian carcinoma patients.
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Tawfik et al. (2022) conducted an observational in Serous ovarian tumors (n=72). FLOT-1 expression vs. FLOT-1 negative was evaluated on Association between FLOT-1 expression and grade of differentiation of serous ovarian carcinoma (p=0.000). FLOT-1 expression was positive in 54% of serous ovarian carcinomas and was significantly associated with the grade of tumor differentiation (p=0.000).
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