The new tricyclic brominated diterpenoid , neorogioltriol ( 1 ), was isolated from the organic extract of the red alga Laurencia glandulifera , collected at Kefalonia Island in Western Greece. Assignment of the 1 H and 13 C NMR resonances were carried out by extensive analysis of its NMR spectra. The new metabolite was evaluated for its analgesic activity using the writhing test in mice and the formalin test in rats. A dose-dependant antiinociceptive response was observed in the writhing test at 0.5 and 1 mg/kg with an IC 50 of 12.5 μg/kg. Compound 1 also inhibited the second phase of the formalin test .
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Chatter et al. (2008) studied this question.
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