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Editorials1 July 1992Estrogen Therapy for Osteoporosis—Even in the ElderlySusan M. Ott, MDSusan M. Ott, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-1-85 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCompared with some of the other consequences of estrogen replacement therapy, the skeletal effects are well defined and noncontroversial. This is in contrast to other effects of estrogen. Despite dozens of studies about the possible risk for breast cancer, two recent meta-analyses have reached opposite conclusions (1, 2). Although most of the epidemiologic studies have found a beneficial effect of estrogen on coronary artery disease (3), the data are not conclusive because the studies of estrogen use and coronary artery disease were not randomized trials. Indeed, women who take estrogen tend to have healthier life-styles, to eat less fat, and...References1. Dupont W and Page D. Menopausal estrogen replacement therapy and breast cancer. Arch Intern Med. 1991;151:67-72. CrossrefMedlineGoogle Scholar2. Steinberg K, Thacker S, Smith J, Stroup D, Zack M, and Flanders D. A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. JAMA. 1991;265:1985-90. CrossrefMedlineGoogle Scholar3. Hazzard W. Estrogen replacement and cardiovascular disease: Serum lipids and blood pressure effects. Am J Obstet Gynecol. 1989;161:1847-53. CrossrefMedlineGoogle Scholar4. Barrett-Connor E. Postmenopausal estrogen and prevention bias. Ann Intern Med. 1991;115:455-6. LinkGoogle Scholar5. Walsh B, Schiff I, Rosner B, Greenberg L, Ravnikar V, and Sacks F. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med. 1991; 325:1196-204. CrossrefMedlineGoogle Scholar6. 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Treatment of postmenopausal osteoporosis by transdermal estrogen administration. Ann Intern Med. 1992;117:1-9. LinkGoogle Scholar16. Weiss N, Ure C, Ballard J, Williams A, and Daling J. Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogens. N Engl J Med. 1980;303:1195-8. CrossrefMedlineGoogle Scholar17. Kanis J. Treatment of osteoporotic fracture. Lancet. 1984;1:27-33. CrossrefMedlineGoogle Scholar18. Riis B, Thomsen K, Strom V, and Christiansen C. The effect of percutaneous estradiol and natural progesterone on postmenopausal bone loss. Am J Obstet Gynecol. 1987;156:61-5. CrossrefMedlineGoogle Scholar19. Stevenson J, Cust M, Ganger K, Hillard T, Lees B, and Whitehead M. Effects of transdermal versus oral hormone replacement therapy on bone density in spine and proximal femur in postmenopausal women. Lancet. 1990;335:265-69. CrossrefMedlineGoogle Scholar20. Ravnikar V. Compliance with hormone therapy. Am J Obstet Gynecol. 1987;156:1332-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Susan M. Ott, MDAffiliations: University of Washington Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byConsiderations of osteoporosis prevention in an aging societyDo Estrogens Effectively Prevent Osteoporosis-Related Fractures?HRT and its impact on the menopause, osteoporosis and breast cancerKnochenstoffwechsel und OsteoporoseOlder Women and Hormone Replacement Therapy: Factors Influencing Late Life InitiationAttitudes and Beliefs of Family Physicians and Gynecologists in Relation to the Prevention and Treatment of OsteoporosisOsteoporosis and Other Disorders of Skeletal AgingAge-related OsteoporosisCALCIUM, ESTROGEN, AND PROGESTIN IN THE TREATMENT OF OSTEOPOROSISOsteoporosis 1 July 1992Volume 117, Issue 1 Page: 85-86 Keywords Breast cancer Elderly Epidemiology Estrogen replacement therapy Estrogens Fats Randomized trials Stable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 July 1992 PDF downloadLoading ...
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