Matters arising tial fibre loss in the smaller range that would be expected to come from small sensory neurons.How much of the neuronal damage was caused by cisplatin and how much by adriamycin cannot be stated, of course, but adriamycin has always been said by clin- icians not to produce a sensory neuropathy; but the ability to detect clinical damage to small sensory neurons is rather limited.From what we know of the mode of action of this and similar agents it is possible that this insensitivity to adriamycin toxicity is more apparant than real.Only careful future studies will show where the truth lies.
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Zihl et al. (1986) studied this question.
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