Toward responsible longevity medicine: Swiss framework for healthy longevity medicine clinics

Introduction Rapid advances in geroscience have catalyzed a proliferation of private longevity clinics while regulatory oversight lags. Switzerland is central to this landscape yet lacks a dedicated framework. We propose a voluntary, hospital-grade framework integrating leadership, evidence generation, cybersecurity, and patient safety—to guide responsible growth.Methods We performed a structured search of PubMed, Embase, and Web of Science (January 2000–March 2025). Eligible human studies and regulatory texts were appraised with GRADE; when multiple sources existed, we prioritized the most recent meta-analyses or largest randomized trials.Results We codify the patient journey into a tiered pathway—risk stratification, multimodal diagnostics, and therapeutic escalation—anchored in extended informed consent, equity safeguards, and public outcome dashboards. Diagnostics (frailty indices to multi-omic clocks) are ranked by analytic validity and clinical utility. Therapeutics (e.g., senotherapeutics, caloric-restriction mimetics, rapalogs) are mapped to evidence tiers and contexts of use. Evidence gaps include pragmatic trials of senotherapeutics, economic validation of composite aging clocks, and ICD-11 recognition of pathological aging.Conclusions This Swiss-aligned framework couples evidence-weighted interventions with system-level transparency. Its adoption could extend healthspan while maintaining scientific rigor, patient safety, and distributive justice across diverse care settings. Implementation should include public dashboards, external audits, and prospectively registry-embedded advanced protocols.