Quick on the uptake: A 20-mer DNA oligomer modified with 5-[(6-guanidiniohexylcarbamoyl)methyl]-2′-deoxyuridine (Tg) shows efficient cellular uptake (blue arrow) in HeLa cells without any other reagents. The fluorescence microscopy image reveals FAM-labeled DNA oligomer (green) and stained nuclei (blue). FAM=6-carboxyfluorescein.
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Ohmichi et al. (2005) studied this question.
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