NMR investigations of stationary phases

An overview of the application of solid‐state and suspended‐state NMR spectroscopy for the characterization of stationary phases is given. Solid‐state 29Si NMR spectroscopy reveals valuable information about the variety and quantity of the surface species formed in the modification reaction. Solid‐state 13C NMR spectroscopy gives an insight into the dynamic properties of the immobilized ligands and ligand organization. With the help of 1H and 13C suspended‐state NMR spectroscopy, investigations can be performed in the presence of a mobile phase. Thus, the structural and dynamic properties of the stationary phase under real‐life chromatographic conditions can be derived from the NMR investigations. These findings can be directly correlated with the resulting chromatographic separation behaviour.