Key result
A rare case of polyarthritis associated with mumps epididymoorchitis in an HIV-infected male patient demonstrated elevated IL-6 serum levels, suggesting its potential as a diagnostic biomarker.
Why the study?
Arthritis is a rare complication of mumps with diverse presentations that make diagnosis challenging, and the underlying mechanisms of joint involvement remain largely unknown.
Case Report (n=1)
IL-6 may serve as a biomarker for the diagnosis of mumps-related arthritis.
May support IL-6 testing in mumps arthritis; leaves open its value as a validated biomarker.
Mumps is a childhood disease with declining incidence in the western world and arthritis is a rare complication associated to the disease. Various presentations exist making diagnosis even more challenging. The mechanisms responsible for the joint involvement remain largely unknown but the timing of onset of the symptoms usually coincide with the rise in antibody titers arguing for an immunologic mediated response. We hereby report a rare case of polyarthritis in the onset of epididymoorchitis due to mumps infection in a HIV infected male patient. Elevated IL-6 serum level in our patient suggests that this cytokine may be an interesting biomarker for the diagnosis of mumps related arthritis.
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Singer et al. (2019) conducted a case report in Mumps infection with epididymoorchitis and polyarthritis (n=1). Mumps infection was evaluated. A rare case of polyarthritis associated with mumps epididymoorchitis in an HIV-infected male patient demonstrated elevated IL-6 serum levels, suggesting its potential as a diagnostic biomarker.
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