Effect of Histidine on the Inhibitory Action of 3-Amino-1,2,4-Triazole

HE present experiments were part of a study to determine the ITmechanisms by which herbicides affect plant growth and to find metabolites which protect growth against the inhibitory actions of herbicides. Bakers' yeast was selected for use in preliminary investigations because its rapid growth rate facilitates examination of large numbers of herbicide-metabolite combinations. The experiments reported herein present evidence which implicates histidine metabolism as a growth process which is sensitive to 3-amino-1,2,4triazole [amitrole].2