A high activity against filaria is demonstrated by l,3-bis[p-aminobenzyl-(idene)amino]imidazolium salts such as 2. Synthesis of 2 involves amination of 2-phenylimidazole with o-(diphenylphosphinoyl)hydroxylamine (DPH) and condensation of the 1,3-diamino product 1 with p-dimethylaminobenzaldehyde. Derivatives of 2 that are unsymmetrically substituted and/or aminated in position 2 are also accessible.
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Link et al. (1990) studied this question.