Answers are grounded in this paper and cite their sources.
Chiral 2‐amino‐1,3‐butadienes 1 derived from commercially available (S)‐2‐methoxymethylpyrrolidine react with aromatic N‐trimethylsilylaldimines and N‐phenylaldimines in the presence of ZnCl2 to give, after the reaction workup, 4‐piperidones 4 and 6, respectively, with moderate to very high enantiomeric excesses. In addition, the absolute configurations of derivatives of 4 a and 4 g were determined by circular dichroism and NMR spectroscopy on the Mosher ester, respectively.
No takes yet. Share an insight, caveat, or question.
Barluenga et al. (1996) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: