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October 2, 2018Journal of Immunology ResearchOpen Access

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells

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Key result

ZIP and ZnT zinc transporters play crucial roles in mediating zinc influx and efflux in immune cells, presenting potential therapeutic targets for regulating zinc homeostasis.

Population

Immune cells (dendritic cells, T cells, B cells, and mast cells) and mammalian zinc transporters (ZIP and ZnT)

Design

Review

Authors

BBBum-Ho BinAjou UniversityJSJuyeon SeoAmorepacific (South Korea)SKSung Tae KimInje University

Discussion

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Implication

Zinc transporter mechanisms in immune cells are hypothesis-generating; leaves open clinical translation pending targeted studies.

Key Points

  • To review the molecular structures, transport mechanisms, and physiological roles of mammalian ZIP and ZnT zinc transporters across various immune cell types.
  • Synthesized biochemical and structural literature detailing mammalian zinc influx (ZIP) and efflux (ZnT) mechanisms.
  • Evaluated transporter expression and functional roles across dendritic cells, T cells, B cells, and mast cells.
  • Identified 14 human ZIP family members that form homo- or heterodimers with 8 transmembrane domains to mediate cytoplasmic zinc influx.
  • Described 10 ZnT family members characterized by a Y-shaped architecture and large cytoplasmic domain that govern zinc efflux.
  • Determined that elucidating structural motifs in zinc transporters provides direct templates for developing targeted immunomodulatory therapeutics.

Structured PICO

P
Population
Immune cells (dendritic cells, T cells, B cells, and mast cells) and mammalian zinc transporters (ZIP and ZnT)

Understanding the structures and transport mechanisms of ZIP and ZnT transporters in immune cells may provide promising drug targets.

Cite This Study

Bin et al. (2018) conducted a review in Zinc homeostasis in immune cells. ZIP and ZnT zinc transporters was evaluated. ZIP and ZnT zinc transporters play crucial roles in mediating zinc influx and efflux in immune cells, presenting potential therapeutic targets for regulating zinc homeostasis.

synapsesocial.com/papers/6a956641dc88abd75325eef0https://doi.org/10.1155/2018/9365747
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Mouse Model of Acrodermatitis Enteropathica: Loss of Intestine Zinc Transporter ZIP4 (Slc39a4) Disrupts the Stem Cell Niche and Intestine Integrity2012 · 150 citations
  2. 2Regulation of T cell receptor signaling by activation-induced zinc influx2011 · 171 citations
  3. 3Functional Expression of the Human hZIP2 Zinc Transporter2000 · 329 citations
  4. 4Crystal Structure of the Second Domain of the Human Copper Chaperone for Superoxide Dismutase,2000 · 94 citations
  5. 5Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans1997 · 348 citations