Synthesis of novel glycopeptide‐polyoxazoline block copolymers by direct coupling between living anionic and cationic polymerization systems

A novel glycopeptide‐containing block copolymer, poly[O‐(tetra‐O‐acetyl‐β‐D‐glucopyranosyl)‐L‐serine]‐block‐poly(2‐methyl‐2‐oxazoline) (5), was synthesized by mutual termination of living polymerizations of a sugar‐substituted α‐amino acid N‐carboxyanhydride (NCA) (1) and 2‐methyl‐2‐oxazoline (3). 5 was deacetylated to provide the glycopeptide‐polyoxazoline block copolymer, poly[O‐(β‐D‐glucopyranosyl)‐L‐serine]‐block‐poly(2‐methyl‐2‐oxazoline) (6).