Traceless Solid‐Phase Synthesis of 2‐Aminothiazoles: Receptor Tyrosine Kinase Inhibitors with Dual Selectivity for Tie‐2 and VEGFR‐2

A 10-step (!) solid-phase synthesis employing the traceless hydrazide linker provides efficient access to a 2-aminothiazole library (see scheme) that yielded access to a new class of tyrosine kinase inhibitors with dual selectivity for the vascular endothelial growth factor receptor VEGFR-2 and the Tie-2 receptor tyrosine kinases.