Key result
Bovine jugular vein valved xenografts for extracardiac TCPC were associated with a higher risk of thrombosis compared to PTFE conduits (P<.0003) and did not protect against liver fibrosis.
Why the study?
Previous work lacked objective data comparing postoperative outcomes between non-valved conduits and bovine jugular vein valved xenograft (BJV) in extracardiac total cavo-pulmonary connection (TCPC), and the effect of BJV on liver fibrosis was unknown.
Does bovine jugular vein valved xenograft improve outcomes or reduce thrombosis compared to synthetic non-valved conduits in patients undergoing extracardiac TCPC?
Population
206 patients who had extracardiac TCPC from 2002 to 2017
Comparison
BJV vs PET conduits vs PTFE tube
Design
Cohort study
Authors
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BJV conduits in TCPC may not reduce liver fibrosis and show higher thrombosis than PTFE; leaves open optimal conduit selection pending prospective data.
Cohort (n=206)
Does bovine jugular vein valved xenograft improve outcomes or reduce thrombosis compared to synthetic non-valved conduits in patients undergoing extracardiac TCPC?
p-value: p=<.0003
PTFE is the recommended conduit for extracardiac TCPC due to a lower risk of thrombosis compared to BJV and PET, while BJV does not appear to protect against liver fibrosis.
Ismail et al. (2020) conducted a cohort in Extracardiac total cavo-pulmonary connection (TCPC) (n=206). Bovine jugular vein valved xenograft (BJV) vs. Synthetic non-valved conduits (PET and PTFE) was evaluated on Hospital outcomes, conduits thrombosis, reinterventions, and survival (p=<.0003). Bovine jugular vein valved xenografts for extracardiac TCPC were associated with a higher risk of thrombosis compared to PTFE conduits (P<.0003) and did not protect against liver fibrosis.
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