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Bilateral cortical necrosis of the kidneys was observed in rabbits which were treated with large doses of cortisone and then given a single intravenous injection of meningococcal or S. marcescens (P-25) toxin. This lesion did not occur when animals were given injections of cortisone alone, or toxin alone. 2. A similar renal lesion occurred in cortisone-treated Syrian Hamsters following an intraperitoneal injection of P-25 toxin.
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Thomas et al. (1951) studied this question.
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