Key result
A higher HDL-C/apo A-I ratio was significantly associated with a decreased risk of nonalcoholic fatty liver disease (OR 0.353; 95% CI 0.257-0.486; P<0.001).
Why the study?
The study aimed to explore the association between the high-density lipoprotein cholesterol to apolipoprotein A-I ratio (HDL-C/apo A-I) and nonalcoholic fatty liver disease (NAFLD).
Does an increased HDL-C/apo A-I ratio reduce the risk of nonalcoholic fatty liver disease in Chinese adults?
Cross-Sectional (n=9,025)
No
Does an increased HDL-C/apo A-I ratio reduce the risk of nonalcoholic fatty liver disease in Chinese adults?
An increased HDL-C/apo A-I ratio is significantly associated with a lower prevalence of NAFLD in a large Chinese cohort.
Background. This study aimed to explore the association between high-density lipoprotein cholesterol to apolipoprotein A-I ratio (HDL-C/apo A-I) and nonalcoholic fatty liver disease (NAFLD). Methods. A total of 9025 Chinese adults were enrolled in this cross-sectional study, who presented their annual health checkups at Zhenhai Lianhua Hospital, Ningbo, during 2017. Results. The NAFLD prevalence was 33.7%, and HDL-C/apo A-I was significantly decreased in NAFLD patients, as well as in lean NAFLD and in patients with NAFLD-related advanced fibrosis (all P < 0.001 ). The prevalence of NAFLD and components of metabolic syndrome are inversely associated with HDL-C/apo A-I ( P < 0.001 ). Multivariate logistic regression analysis show that HDL-C/apo A-I is inversely associated with the risk of NAFLD (odds ratio: 0.353, 95% confidence interval: 0.257–0.486; P < 0.001 ). Conclusions. Our results suggested that increased HDL-C/apo A-I is significantly associated with a decreased risk of NAFLD.
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Huang et al. (2021) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=9,025). High-density lipoprotein cholesterol to apolipoprotein A-I ratio (HDL-C/apo A-I) was evaluated on Risk of NAFLD (OR 0.353, 95% CI 0.257-0.486, p=<0.001). A higher HDL-C/apo A-I ratio was significantly associated with a decreased risk of nonalcoholic fatty liver disease (OR 0.353; 95% CI 0.257-0.486; P<0.001).
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