Medication Adherence and Treatment Satisfaction in Patients with Myasthenia Gravis: A Cross-Sectional Study

This study aimed to systematically evaluate medication adherence and treatment satisfaction among patients with myasthenia gravis (MG), and to investigate their association and influencing factors. A cross-sectional descriptive study was conducted among 97 MG patients treated at the First Affiliated Hospital of Nanchang University between January and October 2025. Medication adherence was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8). Treatment satisfaction was measured using the 9-item Treatment Satisfaction Questionnaire for Medication (TSQM-9), which includes three dimensions: effectiveness, tolerability, and convenience. Statistical analyses included chi-square tests, multinomial/binary logistic regression, and Spearman correlation analysis. Among the 97 participants, 20 (20.6%) showed low adherence, 53 (54.6%) moderate adherence, and 24 (24.7%) high adherence. Multinomial logistic regression showed that increasing age was independently and negatively associated with moderate-to-high adherence ( p < 0.05). Regarding treatment satisfaction, 52.6%, 13.4%, and 51.5% of patients reported satisfaction with the effectiveness, tolerability, and convenience dimensions, respectively. Higher educational level was independently associated with lower odds of effectiveness satisfaction ( p < 0.05), while immunosuppressant use and difficulty paying for medication were independently associated with lower odds of tolerability and convenience satisfaction, respectively (both p < 0.05). Spearman correlation analysis further revealed that TSQM-9 tolerability scores were positively correlated with anxiety severity (ρ = 0.202, p = 0.047). Overall medication adherence among MG patients was moderate, whereas treatment satisfaction differed across dimensions, with tolerability satisfaction being the lowest. Older age was independently associated with lower medication adherence. Higher educational level was associated with lower effectiveness satisfaction, whereas immunosuppressant use and difficulty paying for medication were associated with lower tolerability and convenience satisfaction, respectively.