Answers are grounded in this paper and cite their sources.
(1982). The Problem of Chemically Reactive Metabolites. Drug Metabolism Reviews: Vol. 13, No. 6, pp. 941-961.
No takes yet. Share an insight, caveat, or question.
James R. Gillette (1982) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: