There is no consensus on the most appropriate way of prescribing the dose of radioactive iodine (RAI) to treat thyrotoxicosis. In recent years, the trend is favouring a simple fixed dose regime. We conducted a pilot audit in 2002 on 40 thyrotoxic patients who received either 7 mCi or 11 mCi RAI in 1995 and 1996 in a district general hospital in England, United Kingdom. Results showed no statistical difference between 7mCi and 11mCi RAI, in all clinical variables examined. The apparent higher cure rate for 7mCi was likely due to more of the “iller” patients ( e.g. larger goitre) receiving 11mCi. Patients with nodular goitre (NG) and large goiter may need more than 11mCi. Overall cure rate was 83%. We concluded that fixed standard doses of RAI is a cost effective and efficient way of administering RAI for the treatment of thyrotoxicosis.
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