Massive Amikacin "Overdose"

Brief Reports1 August 1979Massive Amikacin "Overdose"PETER W. L. HO, M.D., FRANCIS D. PIEN, M.D., NAMIKO KOMINAMI, M.D.PETER W. L. HO, M.D.Search for more papers by this author, FRANCIS D. PIEN, M.D.Search for more papers by this author, NAMIKO KOMINAMI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-2-227 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmikacin, one of the new aminoglycosides, has been reported to cause nephrotoxicity and ototoxicity (primarily cochlear, but also vestibular) (1-3). To our knowledge, acute massive amikacin overdose has not been previously reported.On 4 November 1978, a 60-year-old woman with a long history of hypertension was referred to a community hospital for management of acute subarachnoid hemorrhage. At admission, she complained of severe headaches but was alert. Lumbar puncture yielded grossly bloody spinal fluid. She was begun on aminocaproic acid (Amicar®), 3 g intravenously (i.v.) every 2 h. Initial laboratory results were all within normal limits, including a serum creatinine...References1. LANEWRIGHTBLAIR AGD. Ototoxicity and nephrotoxicity of amikacin: an overview of phase II and phase III experience in the United States. Am J Med. 1977;62:911-8. CrossrefMedlineGoogle Scholar2. LERNERSELIGSOHNMATZ SRG. Comparative clinical studies of ototoxicity and nephrotoxicity of amikacin and gentamicin. Am J Med. 1977;62:919-23. CrossrefMedlineGoogle Scholar3. BLACKLAUWEINSTEINYOUNGHEWITT RWRLW. Ototoxicity of amikacin. Antimicrob Agents Chemother. 1976;9:956-60. CrossrefMedlineGoogle Scholar4. PLANTIERFORREYO'NEILLBLAIRCHRISTOPHERCUTLER JAMATR. Pharmacokinetics of amikacin in patients with normal or impaired renal function: radioenzymatic acetylation assay. J Infect Dis. 1976;134(suppl):S323-30. CrossrefMedlineGoogle Scholar5. SMITHMAXWELLEDWARDSROGERSLIETMAN CRCJP. Nephrotoxicity induced by gentamicin and amikacin. Johns Hopkins Med J. 1978;142:85-90. MedlineGoogle Scholar6. LAUYOUNGBLACK WLR. Comparative efficacy and toxicity of amikacin/carbenicillin versus gentamicin/carbenicillin in leukopenic patients: a randomized prospective trial. Am J Med. 1977;62:959-66. CrossrefMedlineGoogle Scholar7. SMITHBAUGHMANEDWARDSROGERSLIETMAN CKCJP. Controlled comparison of amikacin and gentamicin. N Engl J Med. 1977;296:349-53. CrossrefMedlineGoogle Scholar8. MADHAVANYAREMCHUKLEVIN TKN. Effect of renal failure and dialysis on the serum concentration of the aminoglycoside amikacin. Antimicrob Agents Chemother. 1976;10:464-6. CrossrefMedlineGoogle Scholar9. KIRBYCLARKELIBKEREGAMEY WJRC. Clinical pharmacology of amikacin and kanamycin. J Infect Dis. 1976;134(suppl):S312-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Hawaii School of Public Health University of Hawaii-John Burns School of Medicine Honolulu, Hawaii PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcute Kidney Injury Induced by Antimicrobial Agents in the Elderly: Awareness and Mitigation StrategiesAminoglycosidesAminoglycosidesAntibacterial and Antifungal AgentsAdaptation de la posologie des antibiotiques I. Les aminoglycosidesToxic NephropathiesFirst-exposure adaptive resistance to aminoglycoside antibiotics in vivo with meaning for optimal clinical usePharmacological Considerations for Renal Failure and DialysisTherapy of Toxic NephropathiesPharmacological Aspects of Renal Failure and DialysisFunctional Considerations in Aminoglycoside NephrotoxicityDrugs Five Years Later AmikacinRICHARD D. MEYER, M.D.Management of Amikacin OverdoseDrugs and the KidneyAntibioticsGentamicin HemodialysisDAVID N. CHURCHILL, M.D., DON E. BURTON, M. HENRY GAULT, M.D. 1 August 1979Volume 91, Issue 2Page: 227-228KeywordsCreatinineHypertensionLumbar punctureResearch laboratoriesSubarachnoid hemorrhage Issue Published: 1 August 1979 PDF DownloadLoading ...