Protocols of protein interactomics: Molecular fishing on optical chips and magnetic nanoparticles

In the living systems proteins function through interactions, which produce stable and dynamic protein complexes. Therefore necessity of profound studies of protein functions stipulates expansion of protein-protein interaction research. In the present review we describe experimental methods and protocols of protein interactomics, based on technology of molecular fishing on optical chips and paramagnetic nanoparticles. Both approaches are comparatively evaluated in the present review.