Experimental Pyelonephritis and Hypertension

Article1 July 1963Experimental Pyelonephritis and HypertensionImplications for the Clinical ProblemALVIN P. SHAPIRO, M.D., F.A.C.P.ALVIN P. SHAPIRO, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-37 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe relationships between pyelonephritis and hypertension in man have been debated since the studies of Longcope (1) and of Weiss and Parker (2). These investigators demonstrated that chronic pyelonephritis frequently was associated with hypertensive vascular disease and was seen in patients with accelerated nephrosclerosis in an especially high incidence. Perhaps particularly because these observations were made during an era of increasing concentration on the role of the kidney in the production of hypertension, it rapidly and generally was assumed that chronic pyelonephritis was an important primary cause. Subsequently, opinions about the relative etiologic importance of pyelonephritis in hypertension have ranged...References1. LONGCOPE WT: Chronic bilateral pyelonephritis: its origin and its association with hypertension. Ann. Intern. Med. 11: 149, 1937. LinkGoogle Scholar2. WEISSPARKER SJ: Pyelonephritis: its relation to vascular lesions and to arterial hypertension. Medicine 18: 221, 1939. CrossrefGoogle Scholar3. BELL ET: Renal Diseases, 2d ed., Lea & Febiger, Philadelphia, 1950, p. 307. Google Scholar4. SAPHIRCOHEN ONA: Chronic pyelonephritis lenta and the malignant phase of hypertension. Arch. Intern. Med. (Chicago) 104: 748, 1959. CrossrefMedlineGoogle Scholar5. 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BRENNERGILBERT BMVE: Elevated levels of lactic dehydrogenase, glutamic-oxalacetic transaminase, and catalase in infected urine. Amer. J. Med. Sci. 245: 31, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, PennsylvaniaFrom the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.The research referred to in this report has been supported by grants from the United States Public Health Service, the American Heart Association, and the Health Research and Services Foundation of the United Fund of Allegheny County.Requests for reprints should be addressed to Alvin P. Shapiro, M.D., Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 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