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A commonly used anticonvulsant, diphenylhydantoin (Dilantin), decreases the bursting pacemaker activity in certain cells of Aplysia. Dilantin decreases this bursting activity whether it is endogenous to the cell or induced by a convulsant agent. The sodium-dependent negative resistance characteristic which is essential for bursting behavior is reduced in the presence of Dilantin.
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Johnston et al. (1975) studied this question.
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