effects of ERT may be related to hormones other than estrogen. In their accompanying Editorial, Drs Resnick and Henderson 4 suggesttheideaofa“criticalperiod”forthetimingofERT. Such a temporal effect might be better explained by changes in the concentrations of gonadotropins during the postmenopausal period. In the early postmenopausal years, serum gonadotropins are extremely elevated but subsequently decline, 2 andthereforeearlyestrogenreplacementmightbemore
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Smith et al. (2003) studied this question.
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