Key result
Elevated troponin T (>0.03 ng/mL) in patients with pulmonary embolism was associated with lower in-hospital survival (79% vs 94%, p<0.001) and a four-times higher risk of in-hospital death.
Why the study?
Does elevated Troponin T predict in-hospital and 1-year mortality in patients with pulmonary embolism?
Cohort (n=563)
No
Does elevated Troponin T predict in-hospital and 1-year mortality in patients with pulmonary embolism?
Absolute Event Rate: 79% vs 94%
p-value: p=<0.001
Elevated Troponin T at presentation is a strong independent predictor of both in-hospital and 1-year mortality in patients with acute pulmonary embolism.
May support closer monitoring in troponin-positive PE; leaves open prospective validation before routine risk-model integration.
We aimed to determine the prognostic value of troponin T (TNT) for in-hospital and 1-yr mortality in a large sample of patients with pulmonary embolism (PE). Patients presenting at the emergency department of a tertiary care centre from January 1998 to December 2006 with PE were included. A blood sample was taken at the time of presentation. To determine in-hospital and 1-yr mortality, data from the hospital records and the national death register were used. TNT was determined in 563 out of 737 patients with proven PE. TNT was elevated (>0.03 ng x mL(-1)) in 27%. In-hospital survival was 79% in TNT-positive patients compared with 94% in TNT-negative patients (p<0.001). 1-yr survival was 71% in TNT-positive patients compared with 90% in TNT-negative patients (p<0.001). Elevated TNT levels meant a four-times higher risk of in-hospital death and a three-times higher risk of 1-yr mortality, even after adjustment for the other most important risk factors of death in this population. Elevated TNT independently predicts in-hospital and 1-yr mortality in patients with acute PE.
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Janata et al. (2009) conducted a cohort in pulmonary embolism (n=563). Elevated troponin T (>0.03 ng/mL) vs. Normal troponin T (≤0.03 ng/mL) was evaluated on In-hospital survival (p=<0.001). Elevated troponin T (>0.03 ng/mL) in patients with pulmonary embolism was associated with lower in-hospital survival (79% vs 94%, p<0.001) and a four-times higher risk of in-hospital death.