Key result
The modified nomogram incorporating the Vasoactive-Inotropic Score demonstrated excellent predictive ability for 30-day mortality after elective cardiac surgery with an AUC of 0.897.
Why the study?
The Vasoactive-Inotropic Score predicts postoperative adverse events well but is not included in modern predictive models; the authors sought to modify the E-CABG registry nomogram to predict 30-day mortality after elective cardiac surgery.
Does a modified nomogram incorporating the Vasoactive-Inotropic Score improve prediction of 30-day mortality in patients undergoing elective cardiac surgery with cardiopulmonary bypass?
Cohort (n=158)
No
Does a modified nomogram incorporating the Vasoactive-Inotropic Score improve prediction of 30-day mortality in patients undergoing elective cardiac surgery with cardiopulmonary bypass?
A modified nomogram incorporating the Vasoactive-Inotropic Score demonstrates excellent predictive ability for 30-day mortality after elective cardiac surgery.
Answers are grounded in this paper and cite their sources.
May aid risk stratification in cardiac surgery; leaves open clinical utility pending prospective validation.
Introduction. The Vasoactive-Inotropic Score has been shown as a good predictor of adverse events in postoperative period. Nevertheless, the score is not included in modern predictive models. Objectives. To modify the nomogram that was created as a result of the E-CABG registry trial, and to evaluate the efficacy of the modification to predict 30-day mortality after elective cardiac surgery with cardiopulmonary bypass. Materials and methods. Pre- and intraoperative data of 158 patients who underwent elective cardiac surgery with cardiopulmonary bypass was analyzed. Based on the obtained results, the SYNTAX value in the original nomogram was replaced with the VIS value. The predictive model was evaluated in ROC-analysis. Results. The frequency of 30-day mortality in group was 5,06 %. According to the results of ROC-analysis the modified nomogram has AUC = 0,897 (0.844– 0.951) (p < 0.001). The cut-off value was 12.75 points (sensitivity — 87.5 %; specificity — 86.7 %). Conclusions. The modified nomogram has an excellent predictive ability for 30-day mortality.
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Berikashvili et al. (2021) conducted a cohort in Elective cardiac surgery with cardiopulmonary bypass (n=158). Modified nomogram incorporating Vasoactive-Inotropic Score (VIS) vs. Original nomogram was evaluated on 30-day mortality (AUC 0.897, 95% CI 0.844-0.951, p=<0.001). The modified nomogram incorporating the Vasoactive-Inotropic Score demonstrated excellent predictive ability for 30-day mortality after elective cardiac surgery with an AUC of 0.897.
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