An improved synthesis of Bradykinin is described. N‐CBO‐G‐tosyl‐L‐arginyl‐L‐prolyl‐L‐prolyl‐glycine p‐nitrophenyl ester and L‐phenylalanyl‐L‐seryl‐L‐prolyl‐L‐phenylalanyl‐G‐tosyl‐L‐arginine are prepared and condensed together to N‐CBO‐G‐tosyl‐L‐arginyl‐L‐prolyl‐L‐prolyl‐glycyl‐L‐phenylalanyl‐L‐seryl‐L‐prolyl‐L‐phenylalanyl‐G‐tosyl‐L‐arginine. Removal of the protective groups by sodium in liquid ammonia affords directly pure Bradykinin in high yield.
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Guttmann et al. (1962) studied this question.
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