Key result
Membrane repolarization prematurely terminates individual Ca2+ sparks in frog skeletal muscle, resulting in shorter mean rise-times and smaller mean amplitudes compared to maintained depolarization.
Population
Cut segments of single frog skeletal muscle fibers dissected from the ileofibularis muscle (n=11 fibers)
Comparison
Voltage-clamp depolarizations of varying… vs Comparison between different depolarization…
Design
Preclinical
Authors
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Premature spark termination by repolarization in frogs warrants caution extrapolating to humans; leaves open its role in mammalian excitation-contraction coupling.
p-value: p=<0.01
In frog skeletal muscle, individual Ca2+ sparks can be prematurely terminated by repolarization, demonstrating that voltage sensor deactivation can halt Ca2+ release channel activity.
Lacampagne et al. (2000) studied None (Healthy frog skeletal muscle) (n=11). Membrane repolarization vs. Maintained depolarization was evaluated on Ca2+ spark rise-time and amplitude (p=<0.01). Membrane repolarization prematurely terminates individual Ca2+ sparks in frog skeletal muscle, resulting in shorter mean rise-times and smaller mean amplitudes compared to maintained depolarization.
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