Objective To present an additional case of primary biliary cirrhosis complicating coeliac disease. Patient A 63-year-old woman presenting with laboratory signs of cholestasis, but no clinical symptoms. Results Liver biopsy showed primary biliary cirrhosis stage I. The patient was HLA B9-positive. Antibodies were found against mitochondria (M2, M4 and M8), DNA, thryoglobulin, parietal cell antigen and gliadin. Conclusion The association between coeliac disease and primary biliary cirrhosis represents more than a chance combination and appears to be part of a complex autoimmune syndrome with all the classic features of these diseases, such as HLA association and autoimmune antibodies.
No takes yet. Share an insight, caveat, or question.
Löhr et al. (1994) studied this question.