In previous papers we1reported on the utilization of sodiumd-lactate when injected intravenously into normal persons and into patients with acute diffuse hepatic parenchymal injury. As a result of these observations we suggested that the utilization of this substance be employed as a test of hepatic function in the differentiation between jaundice due to extrahepatic obstruction and jaundice due to hepatic damage.2 In the present paper we are reporting on further studies of the utilization of sodiumd-lactate as a test for the differentiation of these two forms of jaundice. The rationale for the use of sodiumd-lactate was described in the previous reports.1The test is dependent essentially on the ability of the intact parenchyma of the liver to convert into glycogen the lactic acid that is circulating in the blood stream. It should again be emphasized that the metabolism ofd-lactate is quite different
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Louis J. Soffer (1938) studied this question.