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May 1, 1966Parasitology

A study of resistance to cycloguanil inPlasmodium gallinaceumin chicks

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Authors

ABAnn BishopAssociation of Research Libraries

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Implication

Experimental animal study demonstrates rapid cycloguanil resistance and proguanil cross-resistance in avian malaria, highlighting shared antifolate resistance pathways.

Key Points

  • To investigate the development of cycloguanil resistance in Plasmodium gallinaceum and determine patterns of cross-resistance to other antimalarial drugs.
  • Passaged Plasmodium gallinaceum through chicks under escalating doses of cycloguanil to generate a drug-resistant strain.
  • Assessed cross-resistance of the cycloguanil-resistant strain against proguanil, pyrimethamine, and chloroquine, and tested reciprocal resistance profiles of proguanil- and pyrimethamine-resistant strains.
  • Maintained parasite passage for 20 months under suppressive cycloguanil regimens and evaluated blood parasitemia clearance using subinoculation.
  • Cycloguanil resistance developed rapidly under drug pressure, conferring cross-resistance to proguanil while parasite sensitivity to pyrimethamine and chloroquine remained intact.
  • Strains selected for high proguanil resistance demonstrated complete resistance to cycloguanil and slight resistance to pyrimethamine, whereas pyrimethamine-resistant parasites exhibited cross-resistance to both proguanil and cycloguanil.
  • Continuous 20-month passage with suppressive cycloguanil doses temporarily cleared blood parasitemia in some birds but failed to eradicate infection or alter drug susceptibility.

Cite This Study

Ann Bishop (1966) studied this question.

synapsesocial.com/papers/6a9585fb3d7e4fca39b2e9a7https://doi.org/10.1017/s0031182000070943
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