One-year supplementation with 54 mg/day of genistein improved left ventricular ejection fraction compared to placebo (20.3 vs -1.67; p=0.040) in postmenopausal women with metabolic syndrome.
RCT (n=22)
Double-blind
Randomized
Does genistein supplementation improve left ventricular systolic function in postmenopausal women with metabolic syndrome?
One-year supplementation with 54 mg/day of genistein improves LV ejection fraction and LA remodeling in postmenopausal women with metabolic syndrome.
Absolute Event Rate: 20.3% vs -1.67%
p-value: p=0.040
Genistein, a soy-derived isoflavone, may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11) or placebo (n = 11) in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV) systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurements. Also, left atrial (LA) morphofunctional indices were investigated at baseline and at the final visit. Results were expressed as median with interquartile range (IQ). A significant improvement of LV ejection fraction (20.3 (IQ 12.5) vs. −1.67 (IQ 24.8); p = 0.040)), and LA area fractional change (11.1 (IQ 22.6) vs. 2.8 (9.5); p = 0.034)) were observed in genistein patients compared to the controls, following 12 months of treatment. In addition, body surface area indexed LA systolic volume and peak LA longitudinal strain significantly changed from basal to the end of the study in genistein-treated patients. One-year supplementation with 54 mg/day of pure genistein improved both LV ejection fraction and LA remodeling and function in postmenopausal women with MetS.
Gregorio et al. (2017) conducted an RCT in Metabolic syndrome (n=22). Genistein vs. Placebo was evaluated on Left ventricular (LV) systolic function (LV ejection fraction) (p=0.040). One-year supplementation with 54 mg/day of genistein improved left ventricular ejection fraction compared to placebo (20.3 vs -1.67; p=0.040) in postmenopausal women with metabolic syndrome.