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Digoxin in 40% propylene glycol and 10% ethanol was injected intramuscularly in 7 patients with auricular fibrillation. Its full cardiac effect was reached in 8 hours, while intravenous digoxin in the same patients reached full effect in 2 hours. Intensity and persistence of action were the same for both routes. Additional intramuscular injections in 26 patients revealed pain but no permanent tissue damage.
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Ganz et al. (1957) studied this question.
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