Chiral Pyridinyloxazolidine Ligands for the Pd-Catalyzed Asymmetric Allylic Alkylation

Asymmetric carbon-carbon bond-forming reaction is one of the most valuable processes for construction of enantiomerically enriched molecules.Considerable research has been done on Pd-catalyzed asymmetric allylic alkylation.1,2In particular, the search of new chiral ligands is an important chapter in the area and remains an area of intense research.We have previously found that phosphinooxazolidines 1 bearing sp nitrogen donor are useful ligands in the asymmetric allylic alkylation.3The oxazolidines obtainable by simple synthetic route seem to be potential ligands for the asymmetric catalysis.As part of our continuing interest in oxazolidines, we herein disclose the preparation of new chiral pyridinyloxazolidines and their application in asymmetric allylic alkylation.