Marrow Aplasia and Sulindac

Letters and Corrections1 January 1980Marrow Aplasia and SulindacJEFFREY L. MILLER, M.D.JEFFREY L. MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-129_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hematologic side effects are known to occur as rare side effects of most nonsteroidal anti-inflammatory drugs. Pancytopenia or granulocytopenia has been observed with tolmetin sodium, naproxen, phenylbutazone, and indomethacin. To our knowledge, this side effect has not previously been reported with sulindac. We present a case of aplastic anemia apparently associated with use of sulindac.A 54-year-old white man with classic ankylosing spondylitis also had apical pulmonary fibrosis and mild Addison's disease. For a recent flare of his sacroiliac pain, naproxen, 250 mg twice daily, was prescribed in March 1979 but was of no help and was...References1. WILLIAMSBEUTLERERSLEVRUNDLES WEAR. Hematology. 2nd ed. New York: McGraw-Hill Book Co.; 1977:258. Google Scholar2. HUSKISSONSCOTT EJ. Sulindac: trials of a new anti-inflammatory drug. Ann Rheum Dis. 1978;37:89-92. CrossrefMedlineGoogle Scholar3. LIEBLINGBENEDEKBOWER MTR. A double-blind, multi-clinic trial of sulindac (MG-213) in the treatment of ankylosing spondylitis. Arthritis Rheum. 1975;18:411. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JEFFREY L. MILLER, M.D.Affiliations: One David Boulevard, Suite 604; Tampa, FL 33606 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulindacNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)Screening pharmaceuticals for possible carcinogenic effects: initial positive results for drugs not previously screenedSulindacReversible bone marrow aplasia induced by naproxenABC of major trauma. Trauma of the spine and spinal cord--I.Aplastic anaemia associated with a non-steroidal anti-inflammatory drug: relapse after exposure to another such drug.Non-steroidal anti-inflammatories in the elderlyNaproxen‐associated aplastic anaemiaNon-steroidal and Analgesic Therapy in the ElderlySULINDAC HEPATOTOXICITY: EFFECTS OF ACUTE AND CHRONIC EXPOSUREAPLASTIC ANEMIA AND ACUTE LEUKEMIA: A POSSIBLE RELATIONSHIP WITH SULINDAC THERAPY?Sulindac Causing a Hypersensitivity Reaction with Peripheral and Mediastinal LymphadenopathyDOUGLAS JAY SPRUNG, M.D.Granulocytosis and a Sulindac OverdoseGARY E. GROSS, M.D.Agranulocytosis and sulindacAnti-inflammatory analgesics and drugs used in rheumatism and goutEXTRAPYRAMIDAL REACTIONS DUE TO DOMPERIDONESULINDAC-INDUCED BONE MARROW TOXICITYAplastic Anemia and SulindacLESLIE BENNETT, M.D., RALPH SCHLOSSMAN, M.D., JEANNE ROSENTHAL, M.D., JEAN DANIEL BALZORA, M.D., ALLEN J. BENNETT, M.D., FRED ROSNER, M.D. 1 January 1980Volume 92, Issue 1Page: 129-129KeywordsAdverse reactionsAnkylosing spondylitisAplastic anemiaBone marrowPulmonary diseasesPulmonary fibrosisSodium ePublished: 1 December 2008 Issue Published: 1 January 1980 PDF downloadLoading ...