impossible to make a distinction if an exan- thema due to /-lactam compounds is mediated by a "toxic" or an immunological mechanism.Therefore, once a rash occurs the best policy is to perform epicutaneous and intracutaneous tests for penicillin allergy, before subsequent administration of ampicillin or related drugs.In this way unexpected, unpleasant reactions may be avoided.
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W H Konarzewski (1982) studied this question.